HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Bromo-3,5-difluorobenzene → 3-(3,5-Difluoro-phenylamino)-6-methyl-pyridine-2-carboxylic acid (4-methyl-thiazol-2-yl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Bromo-3,5-difluorobenzene | HCID 136313 | — |
| Reactant | 6-Methyl-3-(pyridin-3-ylamino)-pyridine-2-carboxylic acid (4-methyl-thiazol-2-yl)-amide | HCID 11537140 | — |
| Product | 3-(3,5-Difluoro-phenylamino)-6-methyl-pyridine-2-carboxylic acid (4-methyl-thiazol-2-yl)-amide | HCID 11544997 | — |
Reaction Steps
The title compound, was prepared from 3-Amino-6-methyl-pyridine-2-carboxylic acid (4-methyl-thiazol-2-yl)-amide (example 14) in accordance with the general method of example 20 using 1-Bromo-3,5-difluorobenzene instead of 3-Bromo-4-methylpyridine to yield the final compound as a yellow solid, MS (ISP): m/e=361.4 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07414060B2 |
| Source dataset | uspto-grants-2008_08 |
| ORD ID | ord-04028f669c1c48a6881f8cb324f53990 |
| Source note | uspto-grants-2008_08 |