1-Bromo-3-fluorobenzene → HCID 86607583, compound

HRID 2219522Notes

Reaction equation

HRID 2219522 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]([NH:9][C:10]([C:12]2[C:17]([NH:18][C:19]3[CH:20]=N[CH:22]=[CH:23][CH:24]=3)=[CH:16][CH:15]=[C:14]([CH3:25])[N:13]=2)=[O:11])=[N:6][C:7]=1[CH3:8].BrC1C=CC=[C:29]([F:33])C=1>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([NH:9][C:10]([C:12]2[C:17]([NH:18][C:19]3[CH:24]=[CH:23][CH:22]=[C:29]([F:33])[CH:20]=3)=[CH:16][CH:15]=[C:14]([CH3:25])[N:13]=2)=[O:11])=[N:6][C:7]=1[CH3:8]

Participants

3

Reactant 2

HCID 140821-Bromo-3-fluorobenzeneHCID 11530141HCID 11530141, compound

Product 1

HCID 86607583HCID 86607583, compound

Procedure

The title compound, was prepared from 3-Amino-6-methyl-pyridine-2-carboxylic acid (5-fluoro-6-methyl-pyridin-2-yl)-amide (example 11) in accordance with the general method of example 20 using 1-Bromo-3-Fluorobenzene instead of 3-Bromo-4-methylpyridine to yield the final compound as a yellow crystalline solid, MS (ISP): m/e=355.3 (M+H+).

Sources & evidence

ORD record
ord-6c9fe75210c54c3780bf5eafc853bf19
Source dataset
uspto-grants-2008_08
Patent number
US07414060B2

Reaction notes

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