1-Bromo-3,5-difluorobenzene → HCID 86607584, compound

HRID 2219523Notes

Reaction equation

HRID 2219523 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]([NH:9][C:10]([C:12]2[C:17]([NH:18]C3C=NC=CC=3)=[CH:16][CH:15]=[C:14]([CH3:25])[N:13]=2)=[O:11])=[N:6][C:7]=1[CH3:8].Br[C:27]1[CH:32]=[C:31]([F:33])[CH:30]=[C:29]([F:34])[CH:28]=1>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([NH:9][C:10]([C:12]2[C:17]([NH:18][C:27]3[CH:32]=[C:31]([F:33])[CH:30]=[C:29]([F:34])[CH:28]=3)=[CH:16][CH:15]=[C:14]([CH3:25])[N:13]=2)=[O:11])=[N:6][C:7]=1[CH3:8]

Participants

3

Reactant 2

HCID 1363131-Bromo-3,5-difluorobenzeneHCID 11530141HCID 11530141, compound

Product 1

HCID 86607584HCID 86607584, compound

Procedure

The title compound, was prepared from 3-Amino-6-methyl-pyridine-2-carboxylic acid (5-fluoro-6-methyl-pyridin-2-yl)-amide (example 11) in accordance with the general method of example 20 using 1-Bromo-3,5-difluorobenzene instead of 3-Bromo-4-methylpyridine to yield the final compound as a light yellow crystalline solid, MS (ISP): m/e=373.1 (M+H+).

Sources & evidence

ORD record
ord-c131967ff95f4173800fffdbcdded576
Source dataset
uspto-grants-2008_08
Patent number
US07414060B2

Reaction notes

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