3-Bromobenzonitrile → HCID 86607585, compound

HRID 2219524Notes

Reaction equation

[F:1][C:2]1[CH:3]=[CH:4][C:5]([NH:9][C:10]([C:12]2[C:17]([NH:18][C:19]3[CH:20]=[N:21][CH:22]=[CH:23][CH:24]=3)=[CH:16][CH:15]=[C:14]([CH3:25])[N:13]=2)=[O:11])=[N:6][C:7]=1[CH3:8].Br[C:27]1C=C(C=C[CH:34]=1)C#N>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([NH:9][C:10]([C:12]2[C:17]([NH:18][C:19]3[CH:20]=[CH:34][CH:27]=[C:23]([C:22]#[N:21])[CH:24]=3)=[CH:16][CH:15]=[C:14]([CH3:25])[N:13]=2)=[O:11])=[N:6][C:7]=1[CH3:8]

Participants

Reactant 2

HCID 233813-Bromobenzonitrile

HCID 11530141HCID 11530141, compound

Product 1

HCID 86607585HCID 86607585, compound

Procedure

The title compound, was prepared from 3-Amino-6-methyl-pyridine-2-carboxylic acid (5-fluoro-6-methyl-pyridin-2-yl)-amide (example 11) in accordance with the general method of example 20 using 3-Bromobenzonitrile instead of 3-Bromo-4-methylpyridine to yield the final compound as a yellow solid, MS (ISP): m/e=362.3 (M+H+).

Sources & evidence

ORD record: ord-80a4b0b2c0e24ef787d391980d0ff66a
Source dataset: uspto-grants-2008_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07414060B2

Reaction notes

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