3,5-Difluoropyridine → HCID 11660700, compound

HRID 2219534Notes

Reaction equation

HRID 2219534 reaction equation
[CH3:1][O:2][CH2:3][CH2:4][N:5]1[CH:9]=[CH:8][C:7]([NH:10][C:11]([C:13]2[C:18]([NH2:19])=[CH:17][CH:16]=[C:15]([CH3:20])[N:14]=2)=[O:12])=[N:6]1.[F:21][C:22]1[CH:23]=[N:24][CH:25]=[C:26](F)[CH:27]=1>>[CH3:1][O:2][CH2:3][CH2:4][N:5]1[CH:9]=[CH:8][C:7]([NH:10][C:11]([C:13]2[C:18]([NH:19][C:26]3[CH:25]=[N:24][CH:23]=[C:22]([F:21])[CH:27]=3)=[CH:17][CH:16]=[C:15]([CH3:20])[N:14]=2)=[O:12])=[N:6]1

Participants

3

Reactant 2

HCID 6428203,5-DifluoropyridineHCID 86607587HCID 86607587, compound

Product 1

HCID 11660700HCID 11660700, compound

Procedure

The title compound, was prepared from 3-Amino-6-methyl-pyridine-2-carboxylic acid [1-(2-methoxy-ethyl)-1H-pyrazol-3-yl]-amide in accordance with the general method of example, step using 3,5-Difluoropyridine instead of 3-bromopyridineto yield the final compound as a off-white solid, MS (ISP): m/e=371.3 (M+H+).

Sources & evidence

ORD record
ord-889938d3f73e4aa5917ddbd1a90047e7
Source dataset
uspto-grants-2008_08
Patent number
US07414060B2

Reaction notes

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