2-Chloro-4-fluoropyridine → HCID 69352750, compound

HRID 2219537Notes

Reaction equation

HRID 2219537 reaction equation
[CH3:1][O:2][CH2:3][CH2:4][N:5]1[CH:9]=[CH:8][C:7]([NH:10][C:11]([C:13]2[C:18]([NH2:19])=[CH:17][CH:16]=[C:15]([CH3:20])[N:14]=2)=[O:12])=[N:6]1.Cl[C:22]1[CH:27]=[C:26]([F:28])[CH:25]=[CH:24][N:23]=1>>[CH3:1][O:2][CH2:3][CH2:4][N:5]1[CH:9]=[CH:8][C:7]([NH:10][C:11]([C:13]2[C:18]([NH:19][C:22]3[CH:27]=[C:26]([F:28])[CH:25]=[CH:24][N:23]=3)=[CH:17][CH:16]=[C:15]([CH3:20])[N:14]=2)=[O:12])=[N:6]1

Participants

3

Reactant 2

HCID 27827922-Chloro-4-fluoropyridineHCID 86607587HCID 86607587, compound

Product 1

HCID 69352750HCID 69352750, compound

Procedure

The title compound, was prepared from 3-Amino-6-methyl-pyridine-2-carboxylic acid [1-(2-methoxy-ethyl)-1H-pyrazol-3-yl]-amide in accordance with the general method of example) step using 2-Chloro-4-fluoropyridine instead of 3-bromopyridineto yield the final compound as a off-white solid, MS (ISP): m/e=371.4 (M+H+).

Sources & evidence

ORD record
ord-b21576d2728c4457b8630603fc78d206
Source dataset
uspto-grants-2008_08
Patent number
US07414060B2

Reaction notes

Loading…