1-Bromo-3,5-difluorobenzene → HCID 11661088, compound

HRID 2219541Notes

Reaction equation

HRID 2219541 reaction equation
[CH3:1][O:2][CH2:3][C:4]1[N:5]=[C:6]([NH:9][C:10]([C:12]2[C:17]([NH2:18])=[CH:16][CH:15]=[C:14]([CH3:19])[N:13]=2)=[O:11])[S:7][CH:8]=1.Br[C:21]1[CH:26]=[C:25]([F:27])[CH:24]=[C:23]([F:28])[CH:22]=1>>[CH3:1][O:2][CH2:3][C:4]1[N:5]=[C:6]([NH:9][C:10]([C:12]2[C:17]([NH:18][C:21]3[CH:26]=[C:25]([F:27])[CH:24]=[C:23]([F:28])[CH:22]=3)=[CH:16][CH:15]=[C:14]([CH3:19])[N:13]=2)=[O:11])[S:7][CH:8]=1

Participants

3

Reactant 2

HCID 1363131-Bromo-3,5-difluorobenzeneHCID 86607588HCID 86607588, compound

Product 1

HCID 11661088HCID 11661088, compound

Procedure

The title compound, was prepared from 3-Amino-6-methyl-pyridine-2-carboxylic acid (4-methoxymethyl-thiazol-2-yl)-amide in accordance with the general method of example 20 using 1-Bromo-3,5-difluorobenzene instead of 3-bromopyridine to yield the final compound as a yellow solid, MS (ISP): m/e=391 (M+H+).

Sources & evidence

ORD record
ord-4aef47ad02af45c2ac19a93d80d4452d
Source dataset
uspto-grants-2008_08
Patent number
US07414060B2

Reaction notes

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