3-Bromo-5-fluoropyridine → HCID 11653646, compound

HRID 2219542Notes

Reaction equation

HRID 2219542 reaction equation
[CH3:1][O:2][CH2:3][C:4]1[N:5]=[C:6]([NH:9][C:10]([C:12]2[C:17]([NH2:18])=[CH:16][CH:15]=[C:14]([CH3:19])[N:13]=2)=[O:11])[S:7][CH:8]=1.Br[C:21]1[CH:22]=[N:23][CH:24]=[C:25]([F:27])[CH:26]=1>>[CH3:1][O:2][CH2:3][C:4]1[N:5]=[C:6]([NH:9][C:10]([C:12]2[C:17]([NH:18][C:21]3[CH:22]=[N:23][CH:24]=[C:25]([F:27])[CH:26]=3)=[CH:16][CH:15]=[C:14]([CH3:19])[N:13]=2)=[O:11])[S:7][CH:8]=1

Participants

3

Reactant 2

HCID 8202063-Bromo-5-fluoropyridineHCID 86607588HCID 86607588, compound

Product 1

HCID 11653646HCID 11653646, compound

Procedure

The title compound, was prepared from 3-Amino-6-methyl-pyridine-2-carboxylic acid (4-methoxymethyl-thiazol-2-yl)-amide in accordance with the general method of example 20 using 3-Bromo-5-fluoropyridine instead of 3-bromopyridine to yield the final compound as a light yellow solid, MS (ISP): m/e=374.3 (M+H+).

Sources & evidence

ORD record
ord-734869e44ce74c728cf4431e84fc1973
Source dataset
uspto-grants-2008_08
Patent number
US07414060B2

Reaction notes

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