HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Bromo-5-fluoropyridine → 3-(5-Fluoro-pyridin-3-ylamino)-6-methyl-pyridine-2-carboxylic acid (4-cyclopropyl-thiazol-2-yl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Bromo-5-fluoropyridine | HCID 820206 | — |
| Reactant | 3-Amino-6-methyl-pyridine-2-carboxylic acid (4-cyclopropyl-thiazol-2-yl)-amide | HCID 86607589 | — |
| Product | 3-(5-Fluoro-pyridin-3-ylamino)-6-methyl-pyridine-2-carboxylic acid (4-cyclopropyl-thiazol-2-yl)-amide | HCID 11675076 | — |
Reaction Steps
The title compound, was prepared from 3-Amino-6-methyl-pyridine-2-carboxylic acid (4-cyclopropyl-thiazol-2-yl)-amide in accordance with the general method of example 20 using 3-Bromo-5-fluoropyridine instead of 3-bromopyridine to yield the final compound as a yellow solid, MS (ISP): m/e=370.1 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07414060B2 |
| Source dataset | uspto-grants-2008_08 |
| ORD ID | ord-8cb3f2eec39a4a8d8d85d339d3832306 |
| Source note | uspto-grants-2008_08 |