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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2219555Generated: November 2, 2026

5-Amino-4-methylpyrimidine → 6-Methyl-3-(4-methyl-pyrimidin-5-ylamino)-pyridine-2-carboxylic acid (1-methyl-1H-pyrazol-3-yl)-amide

https://huagongshe.com/reaction/2219555

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-Amino-4-methylpyrimidineHCID 227541—
Reactant3-Bromo-6-methyl-pyridine-2-carboxylic acid (1-methyl-1H-pyrazol-3-yl)-amideHCID 86607590—
Product6-Methyl-3-(4-methyl-pyrimidin-5-ylamino)-pyridine-2-carboxylic acid (1-methyl-1H-pyrazol-3-yl)-amideHCID 11558840—

Reaction Steps

The title compound, was prepared from 3-Bromo-6-methyl-pyridine-2-carboxylic acid (1-methyl-1H-pyrazol-3-yl)-amide in accordance with the general method of Example 78, step 3 using 5-Amino-4-methylpyrimidine instead of 3-Amino-1-methyl-pyrazole to yield the final compound as a light yellow solid, MS (ISP): m/e=324.3 (M+H+).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07414060B2
Source datasetuspto-grants-2008_08
ORD IDord-42972cb5e64c428e9aecbc87913093be
Source noteuspto-grants-2008_08