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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2219556Generated: October 30, 2026

5-Fluoro-6-methylpyridin-2-amine → 3-(5-Fluoro-6-methyl-pyridin-2-ylamino)-6-methyl-pyridine-2-carboxylic acid (1-methyl-1H-pyrazol-3-yl)-amide

https://huagongshe.com/reaction/2219556

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-Fluoro-6-methylpyridin-2-amineHCID 13789841—
Reactant3-Bromo-6-methyl-pyridine-2-carboxylic acid (1-methyl-1H-pyrazol-3-yl)-amideHCID 86607590—
Product3-(5-Fluoro-6-methyl-pyridin-2-ylamino)-6-methyl-pyridine-2-carboxylic acid (1-methyl-1H-pyrazol-3-yl)-amideHCID 11515633—

Reaction Steps

The title compound, was prepared from 3-Bromo-6-methyl-pyridine-2-carboxylic acid (1-methyl-1H-pyrazol-3-yl)-amide in accordance with the general method of Example 78, step 3 using 2-Amino-5-fluoro-6-methylpyridine instead of 3-Amino-1-methyl-pyrazole to yield the final compound as a light yellow solid, MS (ISP): m/e=341 (M+H+).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07414060B2
Source datasetuspto-grants-2008_08
ORD IDord-35b974ec6460434583427c38057052cc
Source noteuspto-grants-2008_08