2-Amino-5-fluoropyridine → 6-Methyl-3-(1-methyl-1H-pyrazol-4-ylamino)-pyridine-2-carboxylic acid (5-fluoro-pyridin-2-yl)-amide

HRID 2219562Notes

Reaction equation

HRID 2219562 reaction equation
C(O[C:4]([C:6]1[C:11]([NH:12][C:13]2[CH:14]=[N:15][N:16]([CH3:18])[CH:17]=2)=[CH:10][CH:9]=[C:8]([CH3:19])[N:7]=1)=[O:5])C.[NH2:20][C:21]1[CH:26]=[CH:25][C:24]([F:27])=[CH:23][N:22]=1>>[F:27][C:24]1[CH:25]=[CH:26][C:21]([NH:20][C:4]([C:6]2[C:11]([NH:12][C:13]3[CH:14]=[N:15][N:16]([CH3:18])[CH:17]=3)=[CH:10][CH:9]=[C:8]([CH3:19])[N:7]=2)=[O:5])=[N:22][CH:23]=1

Participants

3

Reactant 2

HCID 27377012-Amino-5-fluoropyridineHCID 692370476-Methyl-3-(1-methyl-1H-pyrazol-4-ylamino)-pyridine-2-carboxylic acid ethyl ester

Product 1

HCID 866075926-Methyl-3-(1-methyl-1H-pyrazol-4-ylamino)-pyridine-2-carboxylic acid (5-fluoro-pyridin-2-yl)-amide

Procedure

The title compound, was prepared from 6-Methyl-3-(1-methyl-1H-pyrazol-4-ylamino)-pyridine-2-carboxylic acid ethyl ester and 2-Amino-5-fluoropyridine in accordance with the general method of Example 78, step 2 to yield the final compound as a yellow crystalline solid, MS (ISP): m/e=327.1 (M+H+).

Sources & evidence

ORD record
ord-227a3f47b5a94180af4f122f1bdc1c6a
Source dataset
uspto-grants-2008_08
Patent number
US07414060B2

Reaction notes

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