HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,3-Dimethyl-1H-pyrazol-5-amine → 3-(2,5-Dimethyl-2H-pyrazol-3-ylamino)-6-methyl-pyridine-2-carboxylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,3-Dimethyl-1H-pyrazol-5-amine | HCID 520721 | — |
| Reactant | Ethyl 3-bromo-6-methylpicolinate | HCID 69237506 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Product | 3-(2,5-Dimethyl-2H-pyrazol-3-ylamino)-6-methyl-pyridine-2-carboxylic acid ethyl ester | HCID 69236417 | — |
Reaction Steps
The Pd catalyzed coupling of 3-Bromo-6-methyl-pyridine-2-carboxylic acid ethyl ester and 5-Amino-1,3-dimethylpyrazole was performed in accordance with the general method of Example 78, step 3 to yield the title compound as a yellow-cristalline solid, MS (ISP): m/e=275.4 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07414060B2 |
| Source dataset | uspto-grants-2008_08 |
| ORD ID | ord-3bc506501c6c44d08448122599fe95ae |
| Source note | uspto-grants-2008_08 |