2-Amino-5-fluoropyridine → 3-(5-Cyclopropyl-2-methyl-2H-pyrazol-3-ylamino)-6-methyl-pyridine-2-carboxylic acid (5-fluoro-pyridin-2-yl)-amide

HRID 2219572Notes

Reaction equation

HRID 2219572 reaction equation
C(O[C:4]([C:6]1[C:11]([NH:12][C:13]2[N:14]([CH3:21])[N:15]=[C:16]([CH:18]3[CH2:20][CH2:19]3)[CH:17]=2)=[CH:10][CH:9]=[C:8]([CH3:22])[N:7]=1)=[O:5])C.[NH2:23][C:24]1[CH:29]=[CH:28][C:27]([F:30])=[CH:26][N:25]=1>>[F:30][C:27]1[CH:28]=[CH:29][C:24]([NH:23][C:4]([C:6]2[C:11]([NH:12][C:13]3[N:14]([CH3:21])[N:15]=[C:16]([CH:18]4[CH2:19][CH2:20]4)[CH:17]=3)=[CH:10][CH:9]=[C:8]([CH3:22])[N:7]=2)=[O:5])=[N:25][CH:26]=1

Participants

3

Reactant 2

HCID 27377012-Amino-5-fluoropyridineHCID 692362573-(5-Cyclopropyl-2-methyl-2H-pyrazol-3-ylamino)-6-methyl-pyridine-2-carboxylic acid ethyl ester

Product 1

HCID 866075933-(5-Cyclopropyl-2-methyl-2H-pyrazol-3-ylamino)-6-methyl-pyridine-2-carboxylic acid (5-fluoro-pyridin-2-yl)-amide

Procedure

The tide compound, was prepared from 3-(5-Cyclopropyl-2-methyl-2H-pyrazol-3-ylamino)-6-methyl-pyridine-2-carboxylic acid ethyl ester and 2-Amino-5-fluoropyridine in accordance with the general method of Example 78, step 2 to yield the final compound as a yellow cristalline solid, MS (ISP): m/e=367.3 (M+H+).

Sources & evidence

ORD record
ord-bd9c5c93c1c04099ac74e1a10e684677
Source dataset
uspto-grants-2008_08
Patent number
US07414060B2

Reaction notes

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