HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyrimidin-5-amine → Ethyl 6-methyl-3-(5-pyrimidinylamino)-2-pyridinecarboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyrimidin-5-amine | HCID 344373 | — |
| Reactant | Ethyl 3-bromo-6-methylpicolinate | HCID 69237506 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Product | Ethyl 6-methyl-3-(5-pyrimidinylamino)-2-pyridinecarboxylate | HCID 58368053 | — |
Reaction Steps
The Pd catalyzed coupling of 3-Bromo-6-methyl-pyridine-2-carboxylic acid ethyl ester and 5-Amino-pyrimidine (CAS:[591-55-9] (J. Org. Chem., 20, 829 (1955)) was performed in accordance with the general method of Example 78, step 3 to yield the tide compound as a light brown solid, MS (ISP): m/e=259.3 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07414060B2 |
| Source dataset | uspto-grants-2008_08 |
| ORD ID | ord-03c5d9c132504ddcae3956b1aa584b3d |
| Source note | uspto-grants-2008_08 |