HCID 59707074, compound → HCID 59707078, compound

Participants

Reaction Steps

To a solution of 1-(4-tert-butylbenzyl)-3-(4-nitrobenzyl)tetrahydropyrimidin-2-one (K) (500 mg, 1.31 mmol) in abs. MeOH (50 mL) palladium on charcoal (5%, 600 mg) was added. The reaction mixture was subjected to a hydrogen pressure of 2 bar for 20 min at RT. The catalyst was separated by filtration through Celite and the filtrate was concentrated in vacuo. The desired product 1-(4-aminobenzyl)-3-(4-tert-butylbenzyl)-tetrahydropyrimidin-2-one (L) was obtained as a colorless oil (364 mg, 79% of theory).

Provenance & Evidence