Sodium ethoxide → HCID 69237251, compound

Participants

Reaction Steps

To a solution of 0.99 g (2.92 mmol) of 6-Acetoxymethyl-3-tert-butoxycarbonylamino-pyridine-2-carboxylic acid ethyl ester in 15 ml of absolute ethanol was added 0.11 ml (0.3 mmol, 0.1 equiv.) of sodium ethylate 3N /Ethanol. After stirring for 1 h at room temperature, the mixture was extracted with methylene chloride/water. The aqueous phase was extracted three times with methylene chloride. The combined organic phases were dried over magnesium sulfate and concentrated to yield 0.81 g (2.7 mmol, 93%) of the title compound as an off-white solid, MS (ISP): m/e=297.3 (M+H+).

Provenance & Evidence