Trifluoroacetic acid → 3-Amino-6-cyclopropyl-pyridine-2-carboxylic acid (1-methyl-1H-pyrazol-3-yl)-amide

Participants

Reaction Steps

A solution of 70 mg (0.228 mmol) of [6-Cyclopropyl-2-(1-methyl-1H-pyrazol-3-ylcarbamoyl)-pyridin-3-yl]-carbamic acid tert-butyl ester in 3 ml of methylene chloride was treated with 0.26 ml (0.39 g, 3.42 mmol, 15 equiv.) of trifluoroacetic acid. After stirring for 2.5 h at room temperature, the mixture was worked up with Ethyl acetate/Sodium bicarbonate/water to yield 49 mg (0.19 mmol, 83%) of crude title compound as a light yellow solid, MS (ISP): m/e=258.1 (M+H+); which was sufficiently pure to be used directly in the next step.

Provenance & Evidence