Hydrochloric Acid → HCID 59707057, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of compound N (1.12 g, 4.0 mmol) in abs. DMF (30 mL) there were added 4-nitrobenzyl bromide (864 mg, 4.0 mmol), potassium carbonate (1.14 g, 8.30 mmol), and a catalytic amount of potassium iodide under a blanket of argon. The reaction mixture was heated to 75° C. over a period of 4 h. Following cooling, the reaction mixture was poured into a mixture of ice (300 g) and 2N hydrochloric acid solution in H2O (200 mL), and the reaction mixture was stirred for 1 hour. The resulting solid matter was separated through a frit and dried in vacuo over calcium chloride. The desired product 1-(4-tert-butylbenzyl)-3-(4-nitrobenzyl)-1,3-dihydrobenzimidazol-2-one (P) was obtained in an adequately pure form for synthetic purposes in a yield of 1.48 g (89% of theory).

Provenance & Evidence