1-Methyl-4-(4-nitrophenyl)piperidine-2,6-dione → 4-(4-Amino-phenyl)-1-methyl-piperidine-2,6-dione

Participants

Reaction Steps

A suspension of 348 mg (1.40 mmol) of 1-methyl-4-(4-nitro-phenyl)-piperidine-2,6-dione (as prepared in the previous step) in MeOH (10 mL) was hydrogenated over 10% Pd/C at 20 psi for 1 h at RT. The mixture was filtered through Celite, the filter cake was washed with MeOH, and the solvents were evaporated in vacuo to afford 289 mg (94%) of the title compound as an off-white solid: Mass spectrum (ESI, m/z): Calcd. for C12H14N2O2, 219.1 (M+H). found 219.1.

Provenance & Evidence