HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → 2-Chloro-5-fluoropyridine-3-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | 2,6-Dichloro-5-fluoro-3-pyridinecarbonitrile | HCID 2733849 | — |
| Solvent | Water | HCID 962 | — |
| Product | 2-Chloro-5-fluoropyridine-3-carbonitrile | HCID 23110851 | 52% |
Reaction Steps
Into a 50 mL round bottomed flask, 2,6-dichloro-5-fluoronicotinonitrile (1 g), acetic acid (5 mL) and water (0.5 mL) were charged, and reacted and post-treated in the same manner as in Example 1 and then purified by silica gel column chromatography (hexane/ethyl acetate=6/1) to obtain the title compound (420 mg, yield: 52%). As a result of the HPLC analysis, the purity was 100%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07414136B2 |
| Source dataset | uspto-grants-2008_08 |
| ORD ID | ord-506b4aea7b8946f29064b5c0a5e29d05 |
| Source note | uspto-grants-2008_08 |