反应详情

温度

180 °C

To a mixture of sodium chloride (1.23 g, 21.0 mmol) and aluminum chloride (5.0 g, 38.2 mmol) at 130° C. was added 1-(4-bromophenyl)-4-chlorobutan-1-one (1.0 g, 3.82 mmol) and the resulting mixture was heated to 180° C. for 20 minutes. The mixture was allowed to cool to room temperature and quenched by portionwise addition to a cold 1N HCl solution (150 mL). The mixture was extracted several times with dichloromethane. The combined organic layers were separated, dried over magnesium sulfate, filtered, and concentrated to give 5-bromo-3-methyl-indan-1-one (0.77 g, 89%).

1. temperatureto cool to room temperature
2. customquenched by portionwise addition to a cold 1N HCl solution (150 mL)
3. extractionThe mixture was extracted several times with dichloromethane
4. customThe combined organic layers were separated
5. dry with materialdried over magnesium sulfate
6. filtrationfiltered
7. concentrationconcentrated