反应详情

Fluvastatin methyl ester (3.0 g) was dissolved in acetone (30 ml) and NaOH (0.29 g) partially dissolved in acetone (0.75 ml) was added. The mixture was stirred at room temperature overnight. The product was isolated by filtration under nitrogen, washed with acetone (40 ml) and dried at 50° C. in a vacuum oven for 24 h to obtain 2.31 g (76.2%) of fluvastatin sodium crystal Form I.

1. additionwas added
2. customThe product was isolated by filtration under nitrogen
3. washwashed with acetone (40 ml)
4. customdried at 50° C. in a vacuum oven for 24 h