反应详情

温度

60 °C

Fluvastatin methyl ester (3.01 g) was dissolved in acetonitrile (60 ml) by heating and NaOH (0.28 g) was added. The mixture was stirred at about 60° C. for 1 h, cooled to room temperature, heated again to about 75° C. for 2 h, then cooled to room temperature and stirred overnight. The product was isolated by filtration under nitrogen, washed with acetonitrile (40 ml) and dried at 50° C. in a vacuum oven for 24 h to obtain 1.07 g (34.9%) of fluvastatin sodium crystal Form I.

1. temperatureby heating
2. temperaturecooled to room temperature
3. temperatureheated again to about 75° C. for 2 h
4. temperaturecooled to room temperature
5. stirringstirred overnight
6. customThe product was isolated by filtration under nitrogen
7. washwashed with acetonitrile (40 ml)
8. customdried at 50° C. in a vacuum oven for 24 h