反应详情

温度

40 °C

Fluvastatin methyl ester (3.01 g) was dissolved in acetonitrile (60 ml) by heating and a solution of NaOH (0.28 g) in water (0.75 ml) was added at about 50° C. The mixture was stirred at about 40° C. for 2 h, cooled to room temperature and stirred for another h. The product was isolated by filtration under nitrogen, washed with acetonitrile (40 ml) and dried at 50° C. in a vacuum oven for 24 h to obtain 2.52 g (82.2%) of fluvastatin sodium crystal Form I.

1. temperatureby heating
2. temperaturecooled to room temperature
3. stirringstirred for another h
4. customThe product was isolated by filtration under nitrogen
5. washwashed with acetonitrile (40 ml)
6. customdried at 50° C. in a vacuum oven for 24 h