反应详情

Fluvastatin methyl ester (2.0 g) was added to a solution of NaOH (1 eq.) in methanol (5 ml). The mixture was heated to reflux and stirred for 2.25 h after which the starting material was not longer detected by HPLC. Then, acetonitrile (40 ml) was dripped into the solution in two portions over 1.5 h. The mixture was cooled slowly to room temperature and stirred for another 1.75 h. The product was isolated by filtration under nitrogen, washed with acetonitrile (20 ml) and dried at 50° C. in a vacuum oven for 23 h to obtain 1.7 g (83.4%) of fluvastatin sodium Form VI.

1. temperatureThe mixture was heated
2. temperatureto reflux
3. stirringstirred for another 1.75 h
4. customThe product was isolated by filtration under nitrogen
5. washwashed with acetonitrile (20 ml)
6. customdried at 50° C. in a vacuum oven for 23 h