反应详情

温度

80 °C

Fluvastatin methyl ester (2.0 g) was added to a solution of NaOH (1 eq.) in water (0. 5 ml) and butan-1-ol (8 ml). The mixture was stirred at about 80° C. for 4 h, after which the starting material was not detected by HPLC. Then, acetonitrile (40 ml) was dripped into the solution and the mixture was cooled slowly to room temperature and stirred overnight. The product was isolated by filtration under nitrogen, washed with acetonitrile (15 ml) and dried at 50° C. in a vacuum oven for 24 h to obtain fluvastatin sodium Form VI (1.65 g, 81%).

1. temperaturethe mixture was cooled slowly to room temperature
2. stirringstirred overnight
3. customThe product was isolated by filtration under nitrogen
4. washwashed with acetonitrile (15 ml)
5. customdried at 50° C. in a vacuum oven for 24 h