反应详情

温度

80 °C

Fluvastatin methyl ester (2.0 g) was added to a mixture of NaOH (1 eq.) and butan-1-ol (15 ml). The mixture was stirred at about 80° C. for 1.5 h, after which the starting material was not detected by HPLC. Then, 40 ml of acetone was dripped into the solution and the mixture was cooled slowly to room temperature and stirred overnight. The product was isolated by filtration under nitrogen, washed with acetone (20 ml) and dried at 50° C. in a vacuum oven for 24 h to obtain 1.09 g (53.5%) of fluvastatin sodium Form VII.

1. temperaturethe mixture was cooled slowly to room temperature
2. stirringstirred overnight
3. customThe product was isolated by filtration under nitrogen
4. washwashed with acetone (20 ml)
5. customdried at 50° C. in a vacuum oven for 24 h