Acetonitrile → sodium;(E)-7-[3-(4-fluorophenyl)-1-propan-2-ylindol-2-yl]-3,5-dihydroxyhept-6-enoate

Participants

Reaction Conditions

Reaction Steps

Fluvastatin methyl ester (3.0 g) was added to acetonitrile (60 ml) and the mixture was heating to about 40° C. for dissolution. A solution of NaOH (1 eq.) in EtOH (7.5 ml) was added and turbidity was immediately observed. The mixture then was heated to about 65° C. The mixture was cooled slowly to room temperature and stirred overnight. The product was isolated by filtration under nitrogen, washed with acetonitrile (40 ml) and dried at 50° C. in a vacuum oven for 24 h to obtain fluvastatin sodium Form VII (1.99 g, 64.9%).

Provenance & Evidence