Acetonitrile → sodium;(E)-7-[3-(4-fluorophenyl)-1-propan-2-ylindol-2-yl]-3,5-dihydroxyhept-6-enoate

HRID 2219845Notes

Reaction equation

HRID 2219845 reaction equation
[CH3:1][CH:2]([N:4]1[C:12](/[CH:13]=[CH:14]/[C@H:15]([OH:24])[CH2:16][C@H:17]([OH:23])[CH2:18][C:19]([O:21]C)=[O:20])=[C:11]([C:25]2[CH:30]=[CH:29][C:28]([F:31])=[CH:27][CH:26]=2)[C:10]2[C:5]1=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH3:3].[OH-].[Na+:33].C(#N)C>CO>[CH3:3][CH:2]([N:4]1[C:12](/[CH:13]=[CH:14]/[CH:15]([OH:24])[CH2:16][CH:17]([OH:23])[CH2:18][C:19]([O-:21])=[O:20])=[C:11]([C:25]2[CH:26]=[CH:27][C:28]([F:31])=[CH:29][CH:30]=2)[C:10]2[CH:9]=[CH:8][CH:7]=[CH:6][C:5]1=2)[CH3:1].[Na+:33]

Participants

5

Reactant 3

HCID 6342AcetonitrileHCID 14798Sodium HydroxideHCID 13741557Fluvastatin methyl ester

Product 1

HCID 16760425sodium;(E)-7-[3-(4-fluorophenyl)-1-propan-2-ylindol-2-yl]-3,5-dihydroxyhept-6-enoateYield 60.7%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a three necked flask was added fluvastatin methyl ester (3.0 g) and NaOH (1 eq.) dissolved in MeOH (7.5 ml). The mixture refluxed for 6.5 h. Then, acetonitrile (50 ml) was added dropwise to the refluxing solution over 10 min. The mixture was then cooled to room temperature and stirred for 46 h. The product was isolated by filtration under nitrogen, washed with acetonitrile (50 ml) and dried at 50° C. in a vacuum oven for 24 h to obtain 1.84 g (60.7%) of fluvastatin sodium Form XLVIII.

Workup

  1. temperatureThe mixture refluxed for 6.5 h
  2. customThe product was isolated by filtration under nitrogen
  3. washwashed with acetonitrile (50 ml)
  4. customdried at 50° C. in a vacuum oven for 24 h

Sources & evidence

ORD record
ord-6c31309e78ee437b886ecfb3b0836fc3
Source dataset
uspto-grants-2008_08
Patent number
US07414140B2

Reaction notes

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