反应详情

Fluvastatin (3 g) was completely dissolved in MeOH (15 ml) at reflux temperature. Then, the solution was filtered to obtain a clear solution and heated to reflux again. NaOH (s) (0.29 g) was added at reflux temperature to obtain a precipitate. The slurry was cooled to room temperature to obtain a paste-like mixture. Acetone (30 g) was added dropwise at room temperature and the solution stirred at room temperature for 21 h to obtain a massive precipitate. The product was filtered under nitrogen flow, washed with acetone (2×15 ml) and dried at 50° C. in a vacuum oven for 22.5 h to obtain 1.89 g (62%) of fluvastatin sodium Form XLVIII.

1. temperatureat reflux temperature
2. filtrationThen, the solution was filtered
3. customto obtain a clear solution
4. temperatureheated
5. temperatureto reflux again
6. temperatureat reflux temperature
7. customto obtain a precipitate
8. customto obtain a paste-like mixture
9. customto obtain a massive precipitate
10. filtrationThe product was filtered under nitrogen flow
11. washwashed with acetone (2×15 ml)
12. customdried at 50° C. in a vacuum oven for 22.5 h