反应详情

Fluvastatin (3.52 g) was stirred in a solution of H2O (9.9 ml) and NaOH (s) (0.32 g) at room temperature to obtain a mud-like suspension. The suspension was stirred at room temperature over night. The product was filtered under nitrogen flow, washed with H2O (2×3 ml) and dried at 50° C. in a vacuum oven for 24 h to obtain 3.36 g (65.8%) of fluvastatin sodium Form LIV.

1. customto obtain a mud-like suspension
2. filtrationThe product was filtered under nitrogen flow
3. washwashed with H2O (2×3 ml)
4. customdried at 50° C. in a vacuum oven for 24 h