Sodium Hydroxide → sodium;(E)-7-[3-(4-fluorophenyl)-1-propan-2-ylindol-2-yl]-3,5-dihydroxyhept-6-enoate

Participants

Reaction Steps

Fluvastatin methyl ester (3.0 g) was dissolved in acetone (45 ml) and a solution of NaOH (0.44 g) in MeOH (6 ml) was added. After 29 h, NaOH (0.14 g) was added and the mixture was stirred at room temperature for another 1 h, then it was cooled with ice bath for 30 min. The product was isolated by filtration under nitrogen, washed with acetone (38 ml) and dried at 50° C. in a vacuum oven for 22 h to obtain 2.76 g of fluvastatin sodium crystal Form LXVIII.

Provenance & Evidence