Sodium Hydroxide → sodium;(E)-7-[3-(4-fluorophenyl)-1-propan-2-ylindol-2-yl]-3,5-dihydroxyhept-6-enoate

Participants

Reaction Conditions

Reaction Steps

Fluvastatin methyl ester (8.0 g) was dissolved in acetone (120 ml) and a solution of NaOH (0.75 g) in MeOH (8 ml) was added. The mixture was heated to 50° C. for 4.25 h, cooled to room temperature and stirred over night. NaOH (0.2 g) was added and the mixture was heated again to 50° C. After 5.5 h a solution of NaOH (0.2 g) in MeOH (8 ml) was added and stirred for 1.5 h, then the mixture was cooled to room temperature and stirred for 1 h. The product was isolated by filtration under nitrogen, washed with acetone (100 ml) and dried at 50° C. in a vacuum oven for 21.5 h to obtain 7.26 g of fluvastatin sodium Form CI.

Provenance & Evidence