(R)-(4-azido-3,4-dihydro-2H-chromen-7-yl)methanol → (R)-4-azido-3,4-dihydro-2H-chromene-7-carbaldehyde

Participants

Reaction Steps

To a stirred solution of (R)-(4-azido-3,4-dihydro-2H-chromen-7-yl)methanol (3.293 g, 16.05 mmol) in 50 mL DCM was added manganese dioxide (160.3 mmol, 10.0 eq). The reaction mixture was allowed to stir overnight. A second portion of manganese dioxide (57.84 mmol, 3.5 eq) was added and stirred an additional 4 h. The reaction mixture was filtered and concentrated to yield the aldehyde.

Provenance & Evidence