Potassium tert-butoxide → HCID 178429794, compound

Participants

Reaction Steps

(S)-2-(3-(Trifluoromethyl)benzenesulfonamido)propyl 3-(trifluoromethyl)benzene-sulfonate (1.60 g, 3.26 mmol) was dissolved in 25 mL dry THF and treated with KOtBu (5.0 g, 4.9 mmol). The resulting mixture was stirred for 20 h at RT. Thee reaction mixture was quenched with sat. NH4Cl and the solvent was removed. The residue was partitioned between EtOAc/H2O. The organic layer was washed with sat. NH4Cl, H2O, brine, dried over MgSO4 and concentrated. The residue was purified by SiO2 (90% hexanes: 10% Acetone) to afford the final compound. MS (m/z): 266.1 (M+H) (Calc'd for C10H10F3NO2S: 265.25).

Provenance & Evidence