HCID 86604883, compound → HCID 178527331, compound

HRID 2219887Notes

Reaction equation

HRID 2219887 reaction equation
CC1C[N@@]1S(C1C=CC=C(C(F)(F)F)C=1)(=O)=O.FC(F)(F)C1C=C(S(O[CH2:30][C@H:31]([C:46]2[CH:51]=[CH:50][C:49]([F:52])=[CH:48][CH:47]=2)[NH:32][S:33]([C:36]2[CH:41]=[CH:40][CH:39]=[C:38]([C:42]([F:45])([F:44])[F:43])[CH:37]=2)(=[O:35])=[O:34])(=O)=O)C=CC=1>>[F:52][C:49]1[CH:48]=[CH:47][C:46]([CH:31]2[CH2:30][N@@:32]2[S:33]([C:36]2[CH:41]=[CH:40][CH:39]=[C:38]([C:42]([F:44])([F:43])[F:45])[CH:37]=2)(=[O:34])=[O:35])=[CH:51][CH:50]=1

Participants

3

Reactant 2

HCID 86604883HCID 86604883, compoundHCID 178429794HCID 178429794, compound

Product 1

HCID 178527331HCID 178527331, compound

Procedure

Proceeding as described for (49), but using (S)-2-(4-fluorophenyl)-2-(3-(trifluoromethyl)-benzenesulfonamido)ethyl 3-(trifluoromethyl)benzenesulfonate afforded (S)-2-(4-Fluorophenyl)-1-(3-(trifluoromethyl)benzenesulfonyl)aziridine (50). MS (m/z): 355.2 (M+H) (Calc'd for C15H11F4NO2S: 354.31).

Sources & evidence

ORD record
ord-f2c1e86d10d2440bb635b0952f36913c
Source dataset
uspto-grants-2008_08
Patent number
US07414134B2

Reaction notes

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