HCID 14115006, compound → HCID 69274245, compound

HRID 2219889Notes

Reaction equation

HRID 2219889 reaction equation
C[C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:11][C@H:12]([CH2:14][C:15]#[C:16][Si:17]([CH3:20])([CH3:19])[CH3:18])[CH3:13])(=[O:10])=[O:9])=[CH:4][CH:3]=1.CC1C[N@@]1S(C1C=CC=C([C:34]([F:37])([F:36])[F:35])C=1)(=O)=O>>[F:35][C:34]([F:37])([F:36])[C:7]1[CH:6]=[C:5]([S:8]([NH:11][C@H:12]([CH2:14][C:15]#[C:16][Si:17]([CH3:18])([CH3:19])[CH3:20])[CH3:13])(=[O:9])=[O:10])[CH:4]=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 14115006HCID 14115006, compoundHCID 178429794HCID 178429794, compound

Product 1

HCID 69274245HCID 69274245, compound

Procedure

Proceeding as described for (51), but using (S)-2-methyl-1-(3-(trifluoromethyl)-benzenesulfonyl)aziridine afforded (S)-3-(trifluoromethyl)-N-(5-(trimethylsilyl)pent-4-yn-2-yl)benzenesulfonamide (52). MS (m/z): 364.1 (M+H) (Calc'd for C15H20F3NO2SSi: 363.47).

Sources & evidence

ORD record
ord-0e074a6329e144b3b060f35d8874f4ba
Source dataset
uspto-grants-2008_08
Patent number
US07414134B2

Reaction notes

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