HCID 14115006, compound → HCID 69275466, compound

HRID 2219890Notes

Reaction equation

HRID 2219890 reaction equation
CC1C=CC(S(N[C@H](C[C:15]#[C:16][Si:17]([CH3:20])([CH3:19])[CH3:18])C)(=O)=O)=CC=1.[F:21][C:22]1[CH:27]=[CH:26][C:25]([CH:28]2[CH2:30][N@@:29]2[S:31]([C:34]2[CH:39]=[CH:38][CH:37]=[C:36]([C:40]([F:43])([F:42])[F:41])[CH:35]=2)(=[O:33])=[O:32])=[CH:24][CH:23]=1>>[F:21][C:22]1[CH:27]=[CH:26][C:25]([C@H:28]([NH:29][S:31]([C:34]2[CH:39]=[CH:38][CH:37]=[C:36]([C:40]([F:43])([F:42])[F:41])[CH:35]=2)(=[O:33])=[O:32])[CH2:30][C:15]#[C:16][Si:17]([CH3:20])([CH3:19])[CH3:18])=[CH:24][CH:23]=1

Participants

3

Reactant 2

HCID 14115006HCID 14115006, compoundHCID 178527331HCID 178527331, compound

Product 1

HCID 69275466HCID 69275466, compound

Procedure

Proceeding as described for (51), but using (S)-2-(4-fluorophenyl)-1-(3-(trifluoro-methyl)benzenesulfonyl)aziridine afforded (R)—N-(1-(4-fluorophenyl)-4-(trimethylsilyl)but-3-ynyl)-3-(trifluoromethyl)benzenesulfonamide (53). MS (m/z): 444.3 (M+H) (Calc'd for C20H21F4NO2SSi: 443.54).

Sources & evidence

ORD record
ord-2e9acca5828447389e3c2e4690cffa0a
Source dataset
uspto-grants-2008_08
Patent number
US07414134B2

Reaction notes

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