HCID 69274245, compound → HCID 86604886, compound

HRID 2219892Notes

Reaction equation

HRID 2219892 reaction equation
CC1C=CC(S(N[C@H](CC#C)C)(=O)=O)=CC=1.[F:17][C:18]([F:39])([F:38])[C:19]1[CH:20]=[C:21]([S:25]([NH:28][C@H:29]([CH2:31][C:32]#[C:33][Si](C)(C)C)[CH3:30])(=[O:27])=[O:26])[CH:22]=[CH:23][CH:24]=1>>[CH3:30][C@H:29]([NH:28][S:25]([C:21]1[CH:22]=[CH:23][CH:24]=[C:19]([C:18]([F:39])([F:17])[F:38])[CH:20]=1)(=[O:26])=[O:27])[CH2:31][C:32]#[CH:33]

Participants

3

Reactant 2

HCID 69274245HCID 69274245, compoundHCID 86604885HCID 86604885, compound

Product 1

HCID 86604886HCID 86604886, compound

Procedure

Proceeding as described for (54), but using (S)-3-(trifluoromethyl)-N-(5-(trimethyl-silyl)pent-4-yn-2-yl)benzenesulfonamide afforded (S)—N-(pent-4-yn-2-yl)-3-(trifluoromethyl)-benzenesulfonamide (55). MS (m/z): 292.1 (M+H) (Calc'd for C12H12F3NO2S: 291.29).

Sources & evidence

ORD record
ord-12aad9b8df42430c90f53d80fb168716
Source dataset
uspto-grants-2008_08
Patent number
US07414134B2

Reaction notes

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