HCID 69275466, compound → HCID 86604887, compound

HRID 2219893Notes

Reaction equation

HRID 2219893 reaction equation
CC1C=CC(S(N[C@H](CC#C)C)(=O)=O)=CC=1.[F:17][C:18]1[CH:23]=[CH:22][C:21]([C@H:24]([NH:32][S:33]([C:36]2[CH:41]=[CH:40][CH:39]=[C:38]([C:42]([F:45])([F:44])[F:43])[CH:37]=2)(=[O:35])=[O:34])[CH2:25][C:26]#[C:27][Si](C)(C)C)=[CH:20][CH:19]=1>>[F:17][C:18]1[CH:19]=[CH:20][C:21]([C@H:24]([NH:32][S:33]([C:36]2[CH:41]=[CH:40][CH:39]=[C:38]([C:42]([F:45])([F:43])[F:44])[CH:37]=2)(=[O:35])=[O:34])[CH2:25][C:26]#[CH:27])=[CH:22][CH:23]=1

Participants

3

Reactant 2

HCID 69275466HCID 69275466, compoundHCID 86604885HCID 86604885, compound

Product 1

HCID 86604887HCID 86604887, compound

Procedure

Proceeding as described for (54), but using (R)—N-(1-(4-fluorophenyl)-4-(trimethyl-silyl)but-3-ynyl)-3-(trifluoromethyl)benzenesulfonamide afforded (R)—N-(1-(4-fluoro-phenyl)but-3-ynyl)-3-(trifluoromethyl)benzenesulfonamide (56). MS (m/z): 372.1 (M+H) (Calc'd for C17H13F4NO2S: 371.35).

Sources & evidence

ORD record
ord-a8a0505cb0ee418f8002137b8f95bd96
Source dataset
uspto-grants-2008_08
Patent number
US07414134B2

Reaction notes

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