Lithium Hydroxide → HCID 11664058, compound

Participants

Reaction Conditions

Reaction Steps

(R)-Methyl 3-(1-((R)-7-((4-Fluoropiperidin-1-yl)methyl)-3,4-dihydro-2H-chromen-4-yl)-1H-1,2,3-triazol-4-yl)-2-(4-methylphenylsulfonamido)propanoate (130. mg, 0.228 mmol), 1N LiOH (0.3 mL, 0.3 mmol) in 4 mL MeOH was stirred for 14 h at RT. The reaction mixture was then stirred at 55° C. for 24 h. The reaction mixture was cooled, concentrated and neutralized with 1N HCl. A precipitate formed that was filtered and washed with ether to afford the title compound. MS (m/z): 558.4 (m+H).

Provenance & Evidence