Acetic Acid → HCID 11635202, compound

Participants

Reaction Steps

(2R)-3-(1-(6-Formyl-1,2,3,4-tetrahydronaphthalen-1-yl)-1H-1,2,3-triazol-4-yl)-2-(4-methylphenylsulfonamido)-propanoic acid (85.8 μM, 1 eq) piperidine (3 eq) and HOAc (3 eq) were heated to 40° C. for 3 d. Additional portions of piperidine (3 eq) and HOAc (3 eq) were then added. After 2 h, MP-BH4 was added and the reaction mixture was allowed to stir for 3 days. The reaction mixture was concentrated and was purified using reverse phase conditions C18 (0-100% acetonitrile/water) to afford the title compound. MS (m/z): 538.2 (m+H).

Provenance & Evidence