1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → HCID 69274260, compound

Participants

Reaction Steps

A mixture of (R)-3-(1-((R)-7-((cyclopentylamino)methyl)-3,4-dihydro-2H-chromen-4-yl)-1H-1,2,3-triazol-4-yl)-2-(4-methylphenylsulfonamido)propanoic acid (61 mg, 0.11 mol), HOAt (18 mg, 0.12 mmol), i-Pr2NEt (60. mL, 0.45 mmol), NH4Cl (25 mg, 0.45 mmol), and EDCI (24 mg, 0.12 mmol) in 5 mL DMF was stirred for 24 h at RT. The reaction mixture was concentrated, taken up in H2O, and the white solid was filtered and air-dried to afford the title compound. MS (m/z, m+1): 539.4.

Provenance & Evidence