Diisobutylaluminum hydride → HCID 59771820, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of (R)-5-(4-((R)-3-amino-2-(4-methylbenzenesulfonamido)-3-oxopropyl)-1H-1,2,3-triazol-1-yl)-5,6,7,8-tetrahydronaphthalene-2-carboxylic acid (1.63 g, 3.28 mmol) in 40 mL toluene was added a solution of 1.5M DIBAL-H in toluene. The reaction mixture was stirred for 3 h and then cooled to 0° C. The reaction mixture was quenched by the slow addition of 10% HCl and extracted with EtOAc (3×). The extracts were dried over MgSO4, concentrated and purified by Sio2 (5% MeOH/CH2Cl2) to afford a light yellow solid. MS (m/z): 470.4 (m+H).

Provenance & Evidence