反应详情

A mixture of N-(4-tert-butylphenyl)-7-benzyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-amine (0.359 g, 0.96 mmol), prepared as described in Example 2, ammonium formate (0.304 g, 4.82 mmol) and palladium (10% wt. on activated carbon, 40 mg) in MeOH (5 mL) was stirred at r.t. for one h and then at 60° C. for two h. The mixture was cooled to r.t. and filtered over celite. The filtrate was concentrated under reduced pressure to give a white solid which was dissolved in water. The mixture was extracted twice with a 3:1 mixture of chloroform:isopropanol. The combined organic extracts were dried over sodium sulfate and concentrated to dryness to give 0.26 g (96%) of the title compound which was used directly without further purification.

1. customprepared
2. temperatureThe mixture was cooled to r.t.
3. filtrationfiltered over celite
4. concentrationThe filtrate was concentrated under reduced pressure
5. customto give a white solid which
6. extractionThe mixture was extracted twice with a 3:1 mixture of chloroform
7. dry with materialThe combined organic extracts were dried over sodium sulfate
8. concentrationconcentrated to dryness