4-Tert-Butylaniline → HCID 59021554, compound

HRID 2219928Notes

Reaction equation

HRID 2219928 reaction equation
[CH2:1]([N:8]1[CH2:17][CH2:16][C:15]2[C:14](Cl)=[N:13][C:12]([CH2:19][N:20]3[CH2:25][CH2:24][O:23][CH2:22][CH2:21]3)=[N:11][C:10]=2[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:26]([C:30]1[CH:36]=[CH:35][C:33]([NH2:34])=[CH:32][CH:31]=1)([CH3:29])([CH3:28])[CH3:27]>C(#N)C>[C:26]([C:30]1[CH:31]=[CH:32][C:33]([NH:34][C:14]2[C:15]3[CH2:16][CH2:17][N:8]([CH2:1][C:2]4[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=4)[CH2:9][C:10]=3[N:11]=[C:12]([CH2:19][N:20]3[CH2:25][CH2:24][O:23][CH2:22][CH2:21]3)[N:13]=2)=[CH:35][CH:36]=1)([CH3:29])([CH3:27])[CH3:28]

Participants

4

Reactant 2

HCID 698614-Tert-ButylanilineHCID 59021535HCID 59021535, compound

Product 1

HCID 59021554HCID 59021554, compoundYield 25.4%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

The solution of 7-Benzyl-4-chloro-5,6,7,8-tetrahydro-2-(morpholinomethyl)pyrido[3,4-d]pyrimidine (358 mg, 1 mmol) and 4-tert-butylaniline (179 mg, 1.2 mmol) in acetonitrile (2 mL) was irradiated in microwave at 180° C. for 5 min. Solvent was removed and the residue was dissolved in water, extracted by ethyl acetate, dried over sodium sulfate and purified by column chromatography. Product was obtained as a white foam (120 mg, 25%).

Workup

  1. customSolvent was removed
  2. dissolutionthe residue was dissolved in water
  3. extractionextracted by ethyl acetate
  4. dry with materialdried over sodium sulfate
  5. custompurified by column chromatography

Sources & evidence

ORD record
ord-ef0ffefa1c1e4df6b2f9e8a4e7c05bbb
Source dataset
uspto-grants-2008_08
Patent number
US07414131B2

Reaction notes

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