HuagongsheHuagongshe Chemistry Print Report · For research reference only
Guanidine Hydrochloride → HCID 69221023, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Guanidine Hydrochloride | HCID 5742 | — |
| Reactant | Ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride | HCID 2723880 | — |
| Reactant | Sodium Methoxide | HCID 10942334 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 69221023 | HCID 69221023 | 96% |
Reaction Conditions
| Temperature | 100 °C |
|---|
Reaction Steps
The suspension of ethyl N-benzyl-3-oxo-4-piperidine-carboxylate hydrochloride (2.98 g, 10 mmol) and guanidine hydrochloride (1.15 g, 12 mmol) in the solution of sodium methoxide in methanol (11.5 mL, 25% wt) was stirred at 100° C. in a sealed tube overnight before solvent was removed in vacuo. Residue was dissolved in water (10 mL) and was extracted by CHCl3 and i-PrOH (3:1, 5×80 mL), dried over sodium sulfate. Solvent was removed in vacuo, product was obtained as a light yellow powder (2.45 g, 96%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07414131B2 |
| Source dataset | uspto-grants-2008_08 |
| ORD ID | ord-676c79b6ee1e45bb8eba06015a9eb675 |
| Source note | uspto-grants-2008_08 |