HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2219951Generated: October 31, 2026
Sodium Iodide → 7-benzyl-N-(4-(trifluoromethyl)phenyl)-5,6,7,8-tetrahydro-2-(methylthio)pyrido[3,4-d]pyrimidin-4-amine
https://huagongshe.com/reaction/2219951
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Iodide | HCID 5238 | — |
| Reactant | 4-(Trifluoromethyl)aniline | HCID 9964 | — |
| Reactant | Hydrogen iodide | HCID 24841 | — |
| Reactant | 7-Benzyl-4-chloro-2-(methylthio)-5,6,7,8-tetrahydropyrido[3,4-D]pyrimidine | HCID 52987659 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 7-benzyl-N-(4-(trifluoromethyl)phenyl)-5,6,7,8-tetrahydro-2-(methylthio)pyrido[3,4-d]pyrimidin-4-amine | HCID 59021571 | 73.3% |
Reaction Steps
Sodium iodide (3.9 g, 26 mmol) and hydriodic acid (10 mL, 47% aqueous solution) were added to the solution of 7-benzyl-4-chloro-5,6,7,8-tetrahydro-2-(methylthio)pyrido[3,4-d]pyrimidine (8.0 g, 26 mmol) and 4-aminobenzotrifluoride (5.06 g, 0.031 mol) in dioxane (100 mL) and the reaction solution was stirred at 100° C. overnight. Solid thus formed was filtered out, washed by ethyl acetate and diethyl ether and dried in vacuo. Product was obtained as white needle solid (8.2 g, 73%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07414131B2 |
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| Source dataset | uspto-grants-2008_08 |
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| ORD ID | ord-e9a2474877824807a9030762aed93698 |
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| Source note | uspto-grants-2008_08 |
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