Sodium Iodide → HCID 12003975, compound

Participants

Reaction Steps

Sodium iodide (434 mg, 2.9 mmol) and hydriodic acid (0.4 mL, 47% aqueous solution) were added to the solution 7-benzyl-4-chloro-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine pepare as in Example 1 (500 mg, 1.93 mmol) and 3-aminoquinoline (418 mg, 2.9 mmol) in dioxane (4 mL) and the reaction solution was treated in a microwave at 150° C. for 20 min before solvent was removed. Residue was suspended in water, solid sodium carbonate was added to a pH>8, extracted by ethyl acetate and solvent was removed in vacuo. Residue was purified by column chromatography to yield the product as a beige solid (405 mg, 58%).

Provenance & Evidence